Primary navigation

    Gralise

    Drug - Gralise (gabapentin extended release) [Depomed]

    November 2011

    Therapeutic area - postherpetic neuralgia (PHN)

    Approval criteria

    • Patient must have a diagnosis of postherpetic neuralgia (PHN) AND
    • CrCl > 30 mL/min and not on hemodialysis AND
    • Patient must have an intolerance to; or have tried and failed an adequate trial of a tricyclic antidepressant AND
    • Patient has had a trial of immediate release gabapentin showing some therapeutic benefit and has a compelling therapeutic need to administer gabapentin once daily

    Supply limits

    • Max Daily Dose 300 mg = 1 capsule (34 capsules per 34-day supply) 
    • Max Daily Dose 600 mg = 3 capsules (102 capsules per 34-day supply) 

    Background information

    Gabapentin extended-release (Gralise) oral tablet is a pain response modifier that is indicated for the treatment of postherpetic neuralgia (PHN). Gralise should be titrated to an 1800 mg dose taken orally, once-daily, with the evening meal. Gralise is titrated to effect and a starter pack is available. The 300 mg dose should only be used to achieve a total daily dose that is not in increments of 600 mg, therefore 1 capsule per day is sufficient for a 1 month supply.

    Questions?

    MHCP Provider Call Center 651-431-2700 or 800-366-5411

    back to top