Drug - Ferriprox (deferiprone) [ApoPharma USA, Inc.]
Therapeutic area - Iron Chelator
Approval for use
- Patient has transfusional iron overload due to thalassemia syndromes AND
- Patient has tried and failed deferoxamine or defarasirox
- Special care parameters with Ferriprox use in patients with renal or hepatic impairment are in place (verbal affirmation by physician, pharmacist or nurse is acceptable)
FERRIPROX® (deferiprone) is an iron chelator indicated for the treatment of patients with transfusional iron overload due to thalassemia syndromes when current chelation therapy is inadequate. Approval was based on a reduction in serum ferritin levels. There are no controlled trials demonstrating a direct treatment benefit, such as improvement in disease-related symptoms, functioning, or increased survival.
Limitation of use
Safety and effectiveness have not been established for the treatment of transfusional iron overload in patients with other chronic anemias. No specific studies have been conducted to evaluate its safety and efficacy in patients with renal or hepatic impairment.
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