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DrugXerese (acyclovir/hydrocortisone) 5% acyclovir and 1% hydrocortisone [Meda Pharmaceuticals] 

March 2011

FDA approved indication

Xerese is indicated for the early treatment of recurrent herpes labialis (cold sores) to reduce the likelihood of ulcerative cold sores and to shorten the lesion healing time in adults and adolescents (12 years of age and older).


  • Patient is ≥12 years of age AND
  • Has been diagnosed as having cold sores AND
  • Has used oral acyclovir and valacyclovir for cold sores without benefit AND
  • Has used single agent topical acyclovir concurrently with 1% hydrocortisone for cold sores 


AWP $38.16/gram. Xerese is available as a 5 gram tube.

$190.80/5 grams (DHS payment to pharmacies is about $162/5 grams)


MHCP Provider Call Center 651-431-2700 or 800-366-5411

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