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Opana and Opana ER

DrugOpana and Opana ER (oxymorphone) tablets

March 2008


Oxymorphone is a potent semi-synthetic narcotic analgesic that is a narcotic substitute for morphine. Oral oxymorphone is more potent than oral morphine (3x), hydrocodone (2x), and oxycodone (2x). Elderly patients and renally impaired patients may have a 40-65% increase in bioavailability.

Strengths available


  • 5 mg
  • 10 mg

Opana ER

  • 5 mg
  • 7.5 mg
  • 10 mg
  • 10 mg
  • 15 mg
  • 20 mg
  • 30 mg
  • 40 mg


  • Opana is being used for the relief of moderate to severe pain where the use of an opioid is appropriate AND
  • Patient is under the care of a pain management specialist AND
  • Patient has intolerable side effects to ALL of the opioids listed below, and the adverse effects prevented upward titration of dosage to achieve a satisfactory level of analgesia AND
  • Patient has been warned that:
    • Co-administration with alcohol may increase oxymorphone plasma levels and the risk of potentially fatal toxicity
    • Opana should be taken on an empty stomach since food can increase the rate of absorption by 50% AND
  • Patient does not have moderate and severe hepatic impairment (contraindicated) or a paralytic ileus

Oxymorphone formulation and prior opioid trials required

Immediate-release Hydrocodone with or without acetaminophen (Lorcet, Lortab, Vicoden)
Oxycodone (Percocet, Percodan)
Hydrodmorphone (Dilaudid)
Extended-release Morphine
Fentanyl transdermal


MHCP Provider Call Center 651-431-2700 or 800-366-5411

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