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Bactroban Cream

DrugsBactroban (mupirocin) 2% cream; Bactroban (mupirocin) 2% Nasal ointment

December 2017

Therapeutic area - topical antibiotic


mupirocin 2% ointment 22 gram tubes


  • Bactroban cream (mupirocin 2%) 
  • Bactroban nasal ointment (mupirocin 2%)

* Generic mupirocin 2% ointment is available in 22 gram tubes.

Criteria: Bactroban cream

  • Patient has a skin infection susceptible to mupirocin and which should be treated by a topical antibiotic AND
  • Patient cannot use mupirocin 2% ointment

Criteria: Bactroban (mupirocin) 2% nasal ointment

  • Bactroban Nasal is being used as indicated for the eradication of nasal colonization with methicillin-resistant S. aureus in adult patients and health care workers as part of a comprehensive infection control program to reduce the risk of infection among patients at high risk of methicillin-resistant S. aureus infection during institutional outbreaks of infections with this pathogen. (FDA approved indication) AND
  • Patient cannot otherwise use mupirocin 2% ointment


  • Bactroban (mupirocin) 2% cream is more expensive than mupirocin ointment and there is no evidence to show that mupirocin 2% cream is more effective than mupirocin 2% ointment.
  • Bactroban Nasal is a packaging convenience and is significantly more expensive than a 22 gram tube of mupirocin ointment.
  • Mupirocin ointment 2% can be used in the same manner as the Nasal packaging: (Nasal directions: “A small amount of the ointment about the size of a match head is placed on the little finger and applied to the inside of each nostril. The nostrils are closed by pressing the side of the nose together; this will spread the ointment throughout the nares. A swab may be used for application to infants or patients who are very ill.”)


MHCP Provider Call Center 651-431-2700 or 800-366-5411

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